BIOMEDICINE: Muscle Rejuvenation

Molecular aging and rejuvenation of human muscle stem cells

Very little remains known about the regulation of human organ stem cells (in general, and during the aging process), and most previous data were collected in short-lived rodents. We examined whether stem cell aging in rodents could be extrapolated to genetically and environmentally variable humans. Our findings establish key evolutionarily conserved mechanisms of human stem cell aging. We find ...

Rejuvenation

Elderly people may remember the drug peddlers who frequented the noisy country markets when they were growing up. Even though it was difficult to trust the peddlers, it was even more difficult to resist the temptation to buy their goods. They volubly emphasized that their products could be a silver-bullet potion for rejuvenation. Attracted to such suspicious advertisements, more than a few gull...

Tropical Biomedicine

Biomedicine Select

Autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, are complex disorders characterized by an inflammatory response against the body's own tissues. Recent findings reveal new insights into how these diseases are initiated and progress and the factors that contribute to their clinical symptoms. Such work also pinpoints potential new therapeutic targets including the integra...

Biomedicine Select

This issue’s Biomedicine Select highlights new insights into the role of mitochondria in disease. Several new studies implicate abnormal mitochondria in the destruction of neurons of the substantia nigra, the cause of Parkinson’s disease (PD). Meanwhile, an elegant computational approach has enabled identification of candidate genes for several mitochondrial diseases including the mitochondrial...